ORCESTRA
Orchestration platform for reproducing pharmacogenomic analyses
Description: ORCESTRA is a cloud-based platform that provides a transparent, reproducible and flexible computational framework for processing and sharing high-throughput multimodal biomedical data. The platform enables processing of genomic and pharmacological profiles of cancer samples through the use of automated processing pipelines executed through the Pachyderm data versioning and orchestration tool. ORCESTRA creates an integrated and fully documented data object known as a PharmacoSet (PSet) for future analyses using the Bioconductor PharmacoGx package. A PSet includes cell line and drug annotations, along with molecular and pharmacological data from the largest pharmacogenomic studies and consortia
Authors: Mammoliti A, Smirnov P, Nakano M, Safikhani Z, Eeles C, Seo H, Nair SK, Mer AS, Smith I, Ho C, Beri G, Kusko R; Massive Analysis Quality Control (MAQC) Society Board of Directors; Lin E, Yu Y, Martin S, Hafner M & Haibe-Kains B
Lab: Haibe-Kains
Resource Type: Data Portal
Keywords: Pharmacogenomics, Toxicogenomics, Annotation, Radiomics, Radiogenomics
Licensing: Apache 2.0
Citation
Mammoliti A, Smirnov P, Nakano M, Safikhani Z, Eeles C, Seo H, Nair SK, Mer AS, Smith I, Ho C, Beri G, Kusko R; Massive Analysis Quality Control (MAQC) Society Board of Directors; Lin E, Yu Y, Martin S, Hafner M, Haibe-Kains B. Orchestrating and sharing large multimodal data for transparent and reproducible research. Nat Commun. 2021 Oct 4;12(1):5797. doi: 10.1038/s41467-021-25974-w