DNF Explorer
Explore multi-layer similarities between chemical compounds
Description: A new integrative computational pharmacogenomic approach, referred to as Drug Network Fusion (DNF), to infer scalable drug taxonomies that relies only on basic drug characteristics towards elucidating drug-drug relationships. DNF is the first framework to integrate drug structural information, high-throughput drug perturbation and drug sensitivity profiles, enabling drug classification of new experimental compounds with minimal prior information.
Authors: Nehme El-Hachem, Deena M.A. Gendoo, Laleh Soltan Ghoraie, Zhaleh Safikhani, Petr Smirnov, Christina Chung, Kenan Deng, Ailsa Fang, Erin Birkwood, Chantal Ho, Ruth Isserlin, Gary D. Bader, Anna Goldenberg & Benjamin Haibe-Kains
Lab: Haibe-Kains
Resource Type: Analysis Platform
Keywords: DNF Explorer, pharmacogenomics, drug taxonomy, drug relationships, drug perturbation, drug sensitivity
Licensing:
Citation
Nehme El-Hachem, Deena M.A. Gendoo, Laleh Soltan Ghoraie, Zhaleh Safikhani, Petr Smirnov, Christina Chung, Kenan Deng, Ailsa Fang, Erin Birkwood, Chantal Ho, Ruth Isserlin, Gary D. Bader, Anna Goldenberg, Benjamin Haibe-Kains; Integrative Cancer Pharmacogenomics to Infer Large-Scale Drug Taxonomy. Cancer Res 1 June 2017; 77 (11): 3057–3069. https://doi.org/10.1158/0008-5472.CAN-17-0096