Analysis of Large-Scale Radio-Genomic Data
Description: Computational tool box for radio-genomic analysis which integrates radio-response data, radio-biological modelling and comprehensive cell line annotations for hundreds of cancer cell lines. The 'RadioSet' class enables creation and manipulation of standardized datasets including information about cancer cells lines, radio-response assays and dose-response indicators. Included methods allow fitting and plotting dose-response data using established radio-biological models along with quality control to validate results. Additional functions related to fitting and plotting dose response curves, quantifying statistical correlation and calculating area under the curve (AUC) or survival fraction (SF) are included. For more details please see the included documentation and references.
Authors: Venkata Manem, Petr Smirnov, Ian Smith, Meghan Lambie, Christopher Eeles, Scott Bratman, Benjamin Haibe-Kains
Keywords: RadioGx, radiogenomics, datasets, modelling, annotations, cell lines, visualization, dose-response, statistical analysis, R
Manem, V. S., Lambie, M., Smith, I., Smirnov, P., Kofia, V., Freeman, M., ... & Bratman, S. V. (2019). Modeling cellular response in large-scale radiogenomic databases to advance precision radiotherapy. Cancer Research, 79(24), 6227-6237.