Clustering of Genomic Regions Analysis Method
Description: Provides a new method for identification of clusters of genomic regions within chromosomes. Primarily, it is used for calling clusters of cis-regulatory elements (COREs). 'CREAM' uses genome-wide maps of genomic regions in the tissue or cell type of interest, such as those generated from chromatin-based assays including DNaseI, ATAC or ChIP-Seq. 'CREAM' considers proximity of the elements within chromosomes of a given sample to identify COREs in the following steps: 1) It identifies window size or the maximum allowed distance between the elements within each CORE, 2) It identifies number of elements which should be clustered as a CORE, 3) It calls COREs, 4) It filters the COREs with lowest order which does not pass the threshold considered in the approach.
Authors: Seyed Ali Madani Tonekaboni, Victor Kofia, Mathieu Lupien, Benjamin Haibe-Kains
Keywords: CREAM, clusters, genomic regions, chromosomes, cis-regulatory, R
Licensing: GPL (≥ 3)
Tonekaboni, S. A. M., Mazrooei, P., Kofia, V., Haibe-Kains, B., & Lupien, M. (2017). CREAM: Clustering of genomic REgions Analysis Method. bioRxiv, 222562.