Allele-specific Binding from ChIP-Seq - a tool to identify SNVs causing allele-specific transcription factor binding from ChIP-Seq experiments
Description: Detection of allelic imbalances in ChIP-Seq reads is a powerful approach to identify functional non-coding single nucleotide variants (SNVs), either polymorphisms or mutations, which modulate the affinity of transcription factors for chromatin. We present ABC, a computational tool that identifies allele-specific binding of transcription factors from aligned ChIP-Seq reads at heterozygous SNVs. ABC controls for potential false positives resulting from biases introduced by the use of short sequencing reads in ChIP-Seq and can efficiently process a large number of heterozygous SNVs.
Authors: Bailey S D, Virtanen C, Haibe-Kains B, Lupien M
Bailey, S. D., Virtanen, C., Haibe-Kains, B., & Lupien, M. (2015). ABC: a tool to identify SNVs causing allele-specific transcription factor binding from ChIP-Seq experiments. Bioinformatics, 31(18), 3057-3059.