HPV16-Positive Cell Line Sequencing
CTCF ChIP-Seq, RNA-seq, and ATAC-seq data from 5 patient-derived HPV16-positive cell lines
Description: We used 5 patient-derived HPV16-positive cell lines. Three biological replicates for CTCF ChIP-seq, 1 lane of sequencing for ATAC-seq of each sample, and 4 lanes of sequencing for RNA-seq of each sample. We report that the integration of the human papillomavirus into the host genome increases chromatin accessibility, transcription, and CTCF binding within 100 kbp of the integration site which promotes oncogenesis in some patients.
Authors:
Lab: Hoffman
Release Date: 2020
Keywords: transcriptome, transcripton factor binding, chromatin accessability
Citation
Karimzadeh, M., Arlidge, C., Rostami, A. et al. Human papillomavirus integration transforms chromatin to drive oncogenesis. Genome Biol 24, 142 (2023). https://doi.org/10.1186/s13059-023-02926-930 Samples
Datatype:ChIP-seq, RNA-seq, ATAC-seq
Species:Human
Disease Type:HPV