HPV16-Positive Cell Line Sequencing
CTCF ChIP-Seq, RNA-seq, and ATAC-seq data from 5 patient-derived HPV16-positive cell lines
Description: We used 5 patient-derived HPV16-positive cell lines. Three biological replicates for CTCF ChIP-seq, 1 lane of sequencing for ATAC-seq of each sample, and 4 lanes of sequencing for RNA-seq of each sample. We report that the integration of the human papillomavirus into the host genome increases chromatin accessibility, transcription, and CTCF binding within 100 kbp of the integration site which promotes oncogenesis in some patients.
Authors:
Lab: Hoffman
Year: 2020
Keywords: CTCF, ChIP-seq, RNA-seq, ATAC-seq, HPV, cervical cancer
Citation
Karimzadeh M, Arlidge C, Rostami A, et al. Viral integration transforms chromatin to drive oncogenesis. bioRxiv; 2020. DOI: 10.1101/2020.02.12.942755.30 samples
Sample Type:Homo sapiens, 5 patient-derived HPV16-positive cell lines (93-VU147T, Caski, HMS-001, SCC-090, SiHa)
Species:Human
Datatype:ChIP-seq, RNA-seq, ATAC-seq
Technology:ChIP-seq, RNA-seq, ATAC-seq