Analyze X-linked genetic association for phenotype over all of the potential biological processes
Description: The expression of X-chromosome undergoes three possible biological processes: X-chromosome inactivation (XCI), escape of the X-chromosome inactivation (XCI-E),and skewed X-chromosome inactivation (XCI-S). To analyze the X-linked genetic association for phenotype such as continuous, binary, and time-to-event outcomes with the actual process unknown, we propose a unified approach of maximizing the likelihood or partial likelihood over all of the potential biological processes.
Authors: Wei Xu, Meiling Hao, Yi Zhu
Keywords: xlink, X-chromosome, XCI, likelihood, R
Xu, W., & Hao, M. (2018). A unified partial likelihood approach for X‐chromosome association on time‐to‐event outcomes. Genetic epidemiology, 42(1), 80-94.