SMuRF identifies significantly mutated genomic regions in a set of samples.
Description: SMuRF (Significantly Mutated Region Finder), a user-friendly command-line tool to identify these significantly mutated regions from user-defined genomic intervals and SNVs. We demonstrate this using publicly available datasets in which SMuRF identifies 72 significantly mutated CREs in liver cancer, including known mutated gene promoters as well as previously unreported regions.
Authors: Guilhamon P, Lupien M
Guilhamon, P., & Lupien, M. (2018). SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations. BMC bioinformatics, 19(1), 1-5.